Everyone worries a bit about pain, and no one likes to be pokes with a needle. However, this needle is really small. A topical anesthetic may help a little with the needle poke, but it will not anesthetize the muscle for injection. The muscular pain causes the discomfort. The reality is that the pain associated with neurotoxin injections will vary from patient to patient. At Med Cosmetics Clinic, we counsel of patients to assist them with pain management, such as: deep breathing, squeezing a towel, humming or growling.